dapG [2018-12-03 16:09:13]

aspartokinase I (alpha and beta subunits)

Locus: BSU16760

Isoelectric point: 5.71

Molecular weight: 42.82 kDa

Protein length: 404 aa

Gene length: 1212 bp

Function: biosynthesis of lysine and peptidoglycan

Product: aspartokinase I (alpha and beta subunits)

Essential: yes

E.C.: 2.7.2.4

Synonyms: lssD

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of lysine/ threonine
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
• Groups of genes → Essential genes

Gene

Coordinates: 1,747,123 → 1,748,337

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-aspartate = ADP + 4-phospho-L-aspartate (according to Swiss-Prot)

Protein family

• aspartokinase family (according to Swiss-Prot)

Paralogous protein(s)

• LysC

Effectors of protein activity

• inhibited by diaminopimelic acid PubMed

Structure

• 1SFT (from Geobacillus stearothermophilus, 57% identity) PubMed

Expression and Regulation

Operons

• Genes: asd-dapG-dapA
  Description: PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in SigK regulon
  • SigA: sigma factor, PubMed, in SigA regulon

• Genes: spoVFA-spoVFB-asd-dapG-dapA
  Description: PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in SigK regulon

  Regulation

  • expressed late during sporulation in the mother cell (SigK) PubMed

References

Reviews

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Original publications

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